Mea Hoʻolako Mea ʻAka Sialika
ʻO ka waikawa sialic , i ʻike ʻia hoʻi ʻo N-acetylneuraminic acid (Neu5Ac) , ka waikawa cubilose o ka pūnana manu, he kalapona kūlohelohe ia i hoʻokaʻawale mua ʻia mai nā glycolipids o ka lolo a me nā mucins salivary. No kahi ʻohana ia o nā kō 9-kalapona, me Neu5Ac ke ʻano nui loa a me ke ʻano hana biologically—i mahalo nui ʻia ʻo ia ka ʻāpana hana koʻikoʻi i loko o ka pūnana manu (cubilose), kahi e hoʻohana pinepine ʻia ai kona ʻano ma ke ʻano he hōʻailona maikaʻi.
He kuleana koʻikoʻi ka waikawa Sialic i ka ulu ʻana o ka lolo, ka hoʻoponopono immune, ka hōʻailona cell, a me ke olakino ʻili. I loko o ke kino o ke kanaka, paʻa loa ia i loko o ka lolo, kahi o kona pae ma kahi o 15 mau manawa ma mua o nā kino visceral e like me ke ake a me nā māmā.
Ua noiʻi pū nā haʻawina hou i kona komo ʻana i ka biology tumo, e pili ana i ka modulation immune a me ka metastasis, e hōʻike ana i kona waiwai i nā noi olakino a me ka noiʻi.
ʻO kā mākou sialic acid he mea kūpono ia no ka meaʻai pēpē, nā meaʻai meaʻai, nā meaʻai hana, a me nā mea hoʻonaninani.
noi
Hoʻoikaika i ka ulu ʻana o ka lolo a me ka cognition
He kuleana koʻikoʻi ka waikawa Sialic i ka hana ʻana a me ka hoʻomohala ʻana o ka lolo a me ka ʻōnaehana nerve. Ua hōʻike nā haʻawina i ka hoʻohui ʻana o Neu5Ac i nā ʻiole makuahine i ka wā hāpai e hoʻomaikaʻi i ka hana aʻo a me ka hoʻomanaʻo ʻana o kā lākou mau keiki, e hōʻike ana i ke kuleana o ka sialic acid i ka ulu ʻana o neuronal. Pono nā kamaliʻi a hiki i ka pae ulu ʻana o nā ʻōpio ʻōpio e ʻai i ka nui o ka sialic acid e hōʻoia i ka ulu maʻamau o ka hana o ka lolo. Ma hope o ka hānau ʻana, emi ka pae o ka sialic acid i loko o ke kino o ka makuahine i ka manawa. No laila, ʻo ka hoʻohana mau ʻana i ka waikona sialic kūpono i ka wā hāpai a me ka lactation hiki ke kōkua i ka mālama ʻana i nā pae sialic acid i loko o ke kino o ka makuahine. Aia kekahi pilina ma waena o ka ʻike o ka sialic acid a me ka ʻike o DHA, ʻo ia mau mea ʻelua e pono ai no ka ulu ʻana o ka lolo. He kōkua nō hoʻi ka ʻakika Sialic i nā mākua e hoʻomaikaʻi i ka hoʻomanaʻo.
Hoʻonui i ka palekana
Loaʻa i ka waikawa Sialic ka hana antiviral a hoʻonui i ka pale ʻana o ke kino. ʻAʻole hoʻohaʻahaʻa ʻia ka waikawa Sialic i loko o ka ʻōnaehana digestive a hiki ke komo i ka ʻōpū o ka ʻōpū e hoʻopaʻa i nā microorganism pathogenic, e pale ana iā lākou mai ka adsorbing i nā ʻōpū ʻōpū. ʻAʻole hiki i ka sialic acid i loko o ke kino ke hoʻopaʻa wale i ka maʻi influenza a pale iā ia mai ka hoʻopaʻa ʻana i nā cell kanaka, akā hiki ke hoʻokō i nā hopena antiviral ma ke kāohi ʻana i ka hana o ke koko cytolglutinin a i ʻole neuraminidase ma ka ʻili o ka maʻi influenza.
ʻIli ʻōwili
ʻO Tyrosinase kahi enzyme koʻikoʻi e pili ana i ka melanin synthesis, a hiki i ka Neu5Ac ke kāohi i ka hana tyrosinase, a laila e hōʻemi i ka hana ʻana o ka melanin. Ua hōʻike ʻia nā haʻawina e hoʻohālikelike ʻia nā hopena keʻokeʻo ʻili o Neu5Ac me kekahi mau mea hoʻomaʻemaʻe ʻili kaulana, e like me hydroquinone, arbutin, a me kojic acid. ʻAʻole paʻa paʻa ʻo Arbutin, maʻalahi ka oxidize, hoʻopōʻino ʻia e ka mālamalama a me ka decompose, a ʻo ka hydroquinone a me ka waikona kojic he mea make kino. ʻOkoʻa ke ʻano kemika o Neu5Ac mai nā mea keʻokeʻo i ʻōlelo ʻia ma luna, me ka moiety apo phenolic i pani ʻia e kahi apo glucose. No laila, he mea palekana a me ka pono whitening mea.
ʻAi-hypertensive
Loaʻa i ka Neu5Ac ka mana vasodilatory a hiki ke hoʻoikaika i ka hoʻopaʻa ʻana o nā ʻāpana koko ʻulaʻula ma o ka pale ʻana i ka hōʻuluʻulu ʻana o nā ʻāpana koko. Hoʻopili ʻia ʻo Neu5Ac me ka lipid a i ʻole ka cholesterol metabolism, a me ka hoʻohui ʻana me ka Neu5Ac intake i kahi momona momona hiki ke hoʻomaikaʻi i ka metabolism lipid a me ka coagulation pili i ka hyperlipidemia. No laila, hiki ke hoʻohana ʻia ka sialic acid i mea hoʻohui kūpono no ka antihypertensive a me hyperlipidemia.
ʻAi maʻi maʻi
Hiki i ka waikawa Sialic ke hana ma ke ʻano he immunomodulator ikaika ma ka ʻili o nā maʻi maʻi maʻi, e hāʻawi ana i kahi microenvironment immunosuppressive a me ka pale ʻana i ka maʻi maʻi. Hiki i ka Sialic acid blocking glycomimetics ke hoʻoikaika i ka pale ʻana i ka maʻi maʻi maʻi, hoʻomaikaʻi i ka hoʻopiʻi ʻana i ka maʻi maʻi kūlohelohe kumu-mediated tumor cell killing, a pale i ka metastasis cancer.
Ma nā mākeke honua, ua kapa ʻia hoʻi ka waikawa sialic ʻo acido sialico , e hana ana i kā mākou pauka acido sialico a me nā mea maka acido sialico i mea kūpono no nā mea kūʻai nui a me nā mea hoʻolaha nui e ʻimi nei i kahi mea hana hilinaʻi.
E hoʻomaopopo '
Ling AJW, Chang LS, Babji AS, Latip J, Koketsu M, Lim SJ. Ka nānā ʻana i ka biochemistry o ka waikawa sialic, nā kumu, ka unuhi ʻana a me nā hana me ka kuhikuhi kūikawā i ka pūnana manu ʻai. Kemi meaʻai. 2022 Ian 15;367:130755. doi: 10.1016/j.foodchem.2021.130755.
MY Yew, RY Koh, SM Chye, SA Zainal Abidin, L. Othman, KY Ng. Nā waiwai Neurotrophic a me ka hoʻonohonoho peptide de novo o nā mea i hoʻokaʻawale ʻia mai ka pūnana manu. Food Bioscience, 32 (2019), p. 100466
Xu, Y. Shan, N. Wang, Y. Liu, M. Zhang, M. Ma. Hoʻokomo ʻia ka waikawa Sialic i ka pilina ma waena o ka ovomucin a me ka hemagglutinin a hoʻoikaika i ka hana antiviral o ovomucin International Journal of Biological Macromolecules, 119 (2018), pp. 533-539
Sun, S. Zhang, J. Ren, CC Udenigwe. Nā hoʻolālā i hoʻokumu ʻia i ka waikawa sialic no ka pale ʻana a me ka mālama ʻana i ka maʻi Helicobacter pylori : Nā ʻano hou i ka ʻoihana meaʻai. Nā loiloi koʻikoʻi ma ka ʻepekema meaʻai a me ka meaʻai, 1–12 (2020)
C.-Y. Wang, L.-J. Cheng, B. Shen, Z.-L. Yuan, Y.-Q. Feng, S. Lu. Nā waiwai antihypertensive a me antioxidant o ka sialic acid, ka mea nui o nā pūnana manu hiki ke ʻai ʻia Nā kumuhana i kēia manawa ma ka Nutraceutical Research, 17 (4) (2019), pp. 376-379
Büll, TJ Boltje, N. Balneger, SM Weischer, M. Wassink, JJ Van Gemst, VR Bloemendal, L. Boon, J. Van Der Vlag, T. Heise, MH Den Brok, GJ Adema. Kāohi ʻo Sialic acid blockade i ka ulu ʻana o ka maʻi maʻi ma o ka hoʻonui ʻana i ka maʻi maʻi maʻi t-cell-mediated tumor. Noi'i ma'i 'a'ai, 78 (13) (2018), pp. 3574-3588
ʻO ZCF Wong, GKL Chan, KQY Wub, KKM Poon, Y. Chen, TTX Dong, KWK Tsim. ʻO ka hoʻopau ʻana i ka ʻai ʻana o ka pūnana manu e hoʻokuʻu i ka waikawa N -acetylneuraminic manuahi a me ka peptide liʻiliʻi: He ʻano hana kūpono e hoʻomaikaʻi ai i nā waiwai hana. Food & Function, 9 (10) (2018), pp. 5139-5149
Zolghadri, A. Bahrami, MT Hassan Khan, J. Munoz-Munoz, F. Garcia-Molina, F. Garcia-Canovas, AA Saboury. ʻO kahi loiloi piha e pili ana i ka tyrosinase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 34 (1) (2019), pp. 279-309
Akahana
ʻO ka ʻike i hāʻawi ʻia ma kēia ʻaoʻao no nā kumu ʻepekema a hoʻonaʻauao wale nō. Hoʻokumu ʻia kekahi mau hana i wehewehe ʻia ma ka noiʻi mua a ʻaʻole i loiloi ʻia e nā mana hoʻoponopono. ʻAʻole manaʻo ʻia kēia huahana e hōʻoia, mālama, hoʻōla, a pale paha i kekahi maʻi.
