Loaʻa kahi kikoʻī

Lacto-N-neotetraose (LNnT)

ʻO LNnT maʻemaʻe kiʻekiʻe (≥98%, CAS No. 13007-35-7) no ka ʻōpū microbiota a me ka noiʻi ʻana i ka hana immune.

Māhele:

ʻO Lacto-N-neotetraose (LNnT) he waiu waiu kanaka kūʻokoʻa oligosaccharide (HMO) i haku ʻia me ka glucose, galactose, a me N-acetylglucosamine. Hoʻohālike like me ka Lacto-N-tetraose (LNT), ʻokoʻa ka LNnT i ka pilina glycosidic, e pili ana i kona koho ʻana i nā microbes gut pono e like me Bifidobacteria. He kuleana koʻikoʻi ka LNnT i ka hana ʻana i ka microbiome ʻōpū pēpē, ke kākoʻo ʻana i ka hana immune, a me ka pale ʻana i ka hoʻopili pathogen.

noi

ʻO nā HMO nā mea bioactive koʻikoʻi i ka waiū kanaka, e hāʻawi ana i nā pono olakino he nui e like me ka hoʻolaha ʻana i ke olakino o ka ʻōpū, hoʻonui i ka pale ʻana, kākoʻo i ka ulu ʻana o ka lolo, hoʻemi i ka mumū, pale i nā maʻi, a me ka hakakā ʻana i ka maʻi kanesa. Hoʻohana nui ʻia lākou i loko o nā ʻano pēpē pēpē, nā meaʻai hana, a me nā meaʻai olakino.

 

(1) Paipai i ke ola kino

Hana ʻo HMO ma ke ʻano he prebiotics, koho koho i ka ulu ʻana o nā hua bacteria maikaʻi (e laʻa, Bifidobacteria) a ke keʻakeʻa nei i ka noho ʻana o nā pathogens, no laila e mālama ai i ke koena microbiota o ka ʻōpū.

(2) Hoʻonui i ka Immune System

Hoʻopaʻa nā HMO i nā maʻi pathogen ma o ka hoʻokūkū ʻana me nā pathogens no ka hoʻopaʻa ʻana i nā wahi ma nā ʻaoʻao o ka ʻōpū. Hoʻololi pū lākou i nā hana cell immune a hoʻonui i nā pane kūlohelohe.

(3) Kākoʻo i ka hoʻomohala ʻana i ka lolo

ʻO nā HMO i loaʻa i ka waikawa Sialic (e laʻa, 3′-SL a me 6′-SL) pili i ka hana neuronal a me ka synaptic plasticity, e pāʻani ana i kahi hana koʻikoʻi i ka ulu ʻana o ka lolo pēpē.

(4) Nā hopena anti-inflammatory

Hoʻemi ka HMO i ka mumū o ka ʻōpū a hoʻohaʻahaʻa i nā hōʻailona o ka maʻi ʻōpū ʻeha (IBD).

(5) Kāohi i nā maʻi maʻi

Hoʻemi ka HMO i ka pilikia o nā maʻi ma o ka pale ʻana i nā pathogens (e laʻa, bacteria a me nā maʻi) mai ka hoʻopaʻa ʻana i nā cell host.

(6) Hiki i nā hopena anti-cancer

Hōʻike nā haʻawina e loaʻa paha i nā HMO nā hopena anti-cancer ma o ka hoʻololi ʻana i nā pane kūlohelohe a me ka pale ʻana i ka ulu ʻana o ka maʻi maʻi.

 

 

E hoʻomaopopo '

  1. Okburan G, Kızıler S. Oligosaccharides waiu kanaka e like me ka prebiotics. Pediatr Neonatol. 2023 Mei;64(3):231-238.
  2. Dinleyici M, Barbieur J, Dinleyici EC, Vandenplas Y. Nā hopena hana o ka waiu oligosaccharides kanaka (HMOs). Nā ʻuʻuku ʻuʻuku. 2023 Ian-Dek;15(1):2186115.
  3. Moubareck CA. ʻO ka Microbiota Milk Kanaka a me nā Oligosaccharides: He ʻike i nā pono, nā ʻokoʻa, a me nā pilina. Nā meaʻai. 2021 Mar 29;13(4):1123.
  4. Vandenplas Y, Berger B, Carnielli VP, Ksiazyk J, Lagström H, Sanchez Luna M, Migacheva N, Mosselmans JM, Picaud JC, Possner M, Singhal A, Wabitsch M. Kanaka Milk Oligosaccharides: 2′-Fucosyllactose (2′-FL) a me Lactoose-N.T. Nā meaʻai. 2018 Aug 24;10(9):1161.
  5. Andreas NJ, Kampmann B, Mehring Le-Doare K. Ka waiu waiu kanaka: He loiloi i kona haku mele a me ka bioactivity. Kekahi Hum Dev. 2015 Nov;91(11):629-35.
  6. ʻO Tytgat HLP, Binia A, Austin S, Grathwohl D, Sprenger N. ʻOligosaccharides Milk Kanaka, Nā Mea Bioactive Milk Koʻikoʻi no ke Ola keiki: He Manaʻo. ʻO Nestle Nutr Inst Workshop Ser. 2023;97:30-40.
  7. Zhu L, Li H, Luo T, Deng Z, Li J, Zheng L, Zhang B. ʻOligosaccharides Milk Kanaka: He Manaʻo Koʻikoʻi e pili ana i ke kūkulu ʻana, ka hoʻomākaukau ʻana, ko lākou hiki ke ʻano he meaʻai Bioactive Component, a me nā manaʻo e hiki mai ana. J Kemehana Meaai Agric. 2023 Nov 1;71(43):15908-15925.
  8. Kijner S, Kolodny O, Yassour M. ʻOligosaccharides waiu kanaka a me ka microbiome pēpē pēpē mai kahi hiʻohiʻona eco-evolutionary. Curr Opin Microbiol. 2022 ʻAukake;68:102156.
  9. Zhang B, Li LQ, Liu F, Wu JY. ʻO ka oligosaccharides waiu kanaka a me ka microbiota pēpē pēpē: Nā hana molekala, nā hoʻolālā hoʻohana a me ka hana immune. ʻO Carbohydr Polym. 2022 Ian 15;276:118738.
  10. ʻO Szajewska H. ʻOligosaccharides waiu kanaka i wae ʻia i hoʻohui ʻia i nā ʻano ʻano pēpē no nā keiki liʻiliʻi. ʻO Nestle Nutr Inst Workshop Ser. 2021;96:149-159.
  11. Donovan SM, Comstock SS. ʻO ka waiu waiu kanaka oligosaccharides e hoʻoikaika i ka mucosal neonatal a me ka maʻi ʻōnaehana. Ann Nutr Metab. 2016;69 Mākaukau 2(Suppl 2):42-51.
  12. Salamone M, Di Nardo V. Nā hopena o ka waiu waiu oligosaccharides (HMOs) ma ke olakino o ka ʻōpū. Biosci mua (Elite Ed). 2020 Mar 1;12(1):183-198.
  13. Zhang S, Li T, Xie J, Zhang D, Pi C, Zhou L, Yang W. Gold standard no ka meaʻai: he loiloi o ka waiu waiu oligosaccharide a me kona hopena i ka microbiota pēpē pēpē. Microb Cell Fact. 2021 Mei 28;20(1):108.
  14. Barnett DJM, Endika MF, Klostermann CE, Gu F, Thijs C, Nauta A, Schols HA, Smidt H, Arts ICW, Penders J. Oligosaccharides waiu kanaka, nā lāʻau antimicrobial, a me ka microbiota gut o nā neonates hua'ōlelo: nāʻike mai ka KOALA hānau cohort study. Nā ʻuʻuku ʻuʻuku. 2023 Ian-Dek;15(1):2164152.
  15. Lis-Kuberka J, Orczyk-Pawiłowicz M. Sialylated Oligosaccharides a me Glycoconjugates o ka waiu kanaka. Ka hopena i ka palekana o nā pēpē a me nā keiki hānau hou, ka hoʻomohala ʻana a me ka maikaʻi. Nā meaʻai. 2019 Feb 1;11(2):306.

 

Akahana
ʻO ka ʻike i hāʻawi ʻia ma kēia ʻaoʻao no nā kumu ʻepekema a hoʻonaʻauao wale nō. Hoʻokumu ʻia kekahi mau hana i wehewehe ʻia ma ka noiʻi mua a ʻaʻole i loiloi ʻia e nā mana hoʻoponopono. ʻAʻole manaʻo ʻia kēia huahana e hōʻoia, mālama, hoʻōla, a pale paha i kekahi maʻi.


Nā Manaʻo Kaulana

📞
💬 WhatsApp 📧 Leka uila
 
↑