Salidroside
2-(4-Hydroxyphenyl) ethyl β-D-glucopyranoside
Molecular Formula ：C14H20O7
Molecular Weight：300.30
CAS No：10338-51-9
Structure:
Brief introduction
Salidroside is a natural compound extracted from Rhodiola rosea, belonging to the phenylethanol glycosides class. Rhodiola rosea is a perennial herb that grows in high-altitude regions, primarily found in the Arctic, Northern Europe, Siberia, and the Tibetan Plateau of China. Traditionally, Rhodiola rosea has been used to enhance physical strength, reduce fatigue, improve mental health, and increase adaptability. Salidroside is one of its primary active components, known for its diverse biological activities, and has gained significant attention in medical and health fields in recent years.
Application
1. Anti-Fatigue:
Salidroside enhances energy metabolism by promoting ATP production, thereby boosting energy levels. It also reduces the accumulation of lactic acid and urea after exercise, alleviating muscle fatigue. This makes it particularly suitable for high-intensity athletes or individuals with physically demanding jobs.
2. Antioxidant:
Salidroside exhibits strong antioxidant properties, scavenging free radicals and reducing oxidative stress on cells. This helps delay aging, protect skin health, and prevent chronic diseases related to oxidative stress, such as cardiovascular and neurodegenerative diseases.
3. Anti-Depressant and Mental Health Improvement:
Salidroside modulates neurotransmitters in the brain, such as serotonin, dopamine, and norepinephrine, improving mood and alleviating anxiety and depression. Studies have shown that salidroside can significantly aid in the treatment of mild to moderate depression.
4. Immune Enhancement:
Salidroside activates immune cells, such as T cells and macrophages, enhancing the body's immune response. It also helps balance the immune system, enabling the body to better defend against pathogens.
5. Anti-Inflammatory Effects:
By inhibiting the release of inflammatory mediators (e.g., TNF-α and IL-6), salidroside reduces inflammation. This is particularly beneficial for alleviating inflammatory conditions such as arthritis and enteritis.
6. Cardiovascular Protection:
Salidroside improves blood circulation, lowers cholesterol levels, and prevents atherosclerosis. Additionally, it enhances the antioxidant capacity of myocardial cells, protecting the heart from ischemia-reperfusion injury.
7. Adaptogenic Properties:
Salidroside is known as an "adaptogen," helping the body adapt to various environmental stresses, such as cold, hypoxia, and fatigue. It regulates the hypothalamic-pituitary-adrenal (HPA) axis, enhancing the body's stress resistance.
8. Neuroprotective Effects:
Salidroside protects the nervous system by reducing oxidative damage to neurons and improving cognitive function. Research suggests it may help prevent and treat neurodegenerative diseases such as Alzheimer's and Parkinson's.
References
Liu X, Zhou M, Dai Z, Luo S, Shi Y, He Z, Chen Y. Salidroside alleviates ulcerative colitis via inhibiting macrophage pyroptosis and repairing the dysbacteriosis-associated Th17/Treg imbalance. Phytother Res. 2023 Feb;37(2):367-382
